Keep in mind that the RF values will be completely different if you use other encoders like H.265 or even H.264 with a hardware acceleration encoder. For 1080p, 20-22 is indeed appropriate but lower res like 480p will require a lower RF like 16-18 for the same quality. Meanwhile 4K will be fine with 24. Again, assuming you use the x264 encoder which is not hardware accelerated. For best results, I’d really recommend playing around with the settings and see what works best for you.
Fedora’s my favorite. It’s also the most secure without going straight to QubesOS, which is not beginner friendly.